Effects of Concomitant Immunomodulator Therapy on Efficacy and Safety of Anti-Tumor Necrosis Factor Therapy for Crohn's Disease: A Meta-analysis of Placebo-controlled Trials.
Identifieur interne : 002E76 ( Main/Exploration ); précédent : 002E75; suivant : 002E77Effects of Concomitant Immunomodulator Therapy on Efficacy and Safety of Anti-Tumor Necrosis Factor Therapy for Crohn's Disease: A Meta-analysis of Placebo-controlled Trials.
Auteurs : Jennifer L. Jones [Canada] ; Gilaad G. Kaplan [Canada] ; Laurent Peyrin-Biroulet [France] ; Leonard Baidoo [États-Unis] ; Shane Devlin [Canada] ; Gil Y. Melmed [États-Unis] ; Divine Tanyingoh [Canada] ; Laura Raffals [États-Unis] ; Peter Irving [Royaume-Uni] ; Patricia Kozuch [États-Unis] ; Miles Sparrow [Australie] ; Fernando Velayos [États-Unis] ; Brian Bressler [Canada] ; Adam Cheifetz [États-Unis] ; Jean-Frederic Colombel [États-Unis] ; Corey A. Siegel [États-Unis]Source :
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [ 1542-7714 ] ; 2015.
Descripteurs français
- KwdFr :
- Association de médicaments (), Association de médicaments (effets indésirables), Effets secondaires indésirables des médicaments (anatomopathologie), Effets secondaires indésirables des médicaments (épidémiologie), Essais contrôlés randomisés comme sujet, Facteur de nécrose tumorale alpha (antagonistes et inhibiteurs), Facteurs immunologiques (administration et posologie), Facteurs immunologiques (effets indésirables), Humains, Maladie de Crohn (traitement médicamenteux), Placebo (administration et posologie), Résultat thérapeutique.
- MESH :
- administration et posologie : Facteurs immunologiques, Placebo.
- anatomopathologie : Effets secondaires indésirables des médicaments.
- antagonistes et inhibiteurs : Facteur de nécrose tumorale alpha.
- effets indésirables : Association de médicaments, Facteurs immunologiques.
- traitement médicamenteux : Maladie de Crohn.
- épidémiologie : Effets secondaires indésirables des médicaments.
- Association de médicaments, Essais contrôlés randomisés comme sujet, Humains, Résultat thérapeutique.
English descriptors
- KwdEn :
- Crohn Disease (drug therapy), Drug Therapy, Combination (adverse effects), Drug Therapy, Combination (methods), Drug-Related Side Effects and Adverse Reactions (epidemiology), Drug-Related Side Effects and Adverse Reactions (pathology), Humans, Immunologic Factors (administration & dosage), Immunologic Factors (adverse effects), Placebos (administration & dosage), Randomized Controlled Trials as Topic, Treatment Outcome, Tumor Necrosis Factor-alpha (antagonists & inhibitors).
- MESH :
- chemical , administration & dosage : Immunologic Factors, Placebos.
- adverse effects : Drug Therapy, Combination, Immunologic Factors.
- chemical , antagonists & inhibitors : Tumor Necrosis Factor-alpha.
- drug therapy : Crohn Disease.
- epidemiology : Drug-Related Side Effects and Adverse Reactions.
- methods : Drug Therapy, Combination.
- pathology : Drug-Related Side Effects and Adverse Reactions.
- Humans, Randomized Controlled Trials as Topic, Treatment Outcome.
Abstract
There is debate over whether patients with Crohn's disease who start anti-tumor necrosis factor (TNF) therapy after failed immunomodulator therapy should continue to receive concomitant immunomodulators. We conducted a meta-analysis of subgroups from randomized controlled trials (RCTs) of anti-TNF agents to compare the efficacy and safety of concomitant immunomodulator therapy vs anti-TNF monotherapy.
DOI: 10.1016/j.cgh.2015.06.034
PubMed: 26142167
Affiliations:
- Australie, Canada, France, Royaume-Uni, États-Unis
- Alberta, Angleterre, Californie, Grand Est, Grand Londres, Lorraine (région), Massachusetts, Minnesota, New Hampshire, Pennsylvanie, Victoria (État), État de New York
- Calgary, Londres, Melbourne, Nancy
- Université de Calgary, Université de Lorraine
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Le document en format XML
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Jones</name><affiliation wicri:level="1"><nlm:affiliation>Dalhousie University, Halifax, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Dalhousie University, Halifax</wicri:regionArea><wicri:noRegion>Halifax</wicri:noRegion></affiliation></author><author><name sortKey="Kaplan, Gilaad G" sort="Kaplan, Gilaad G" uniqKey="Kaplan G" first="Gilaad G" last="Kaplan">Gilaad G. Kaplan</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Peyrin Biroulet, Laurent" sort="Peyrin Biroulet, Laurent" uniqKey="Peyrin Biroulet L" first="Laurent" last="Peyrin-Biroulet">Laurent Peyrin-Biroulet</name><affiliation wicri:level="4"><nlm:affiliation>Inserum U954 and Université de Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserum U954 and Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Baidoo, Leonard" sort="Baidoo, Leonard" uniqKey="Baidoo L" first="Leonard" last="Baidoo">Leonard Baidoo</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Devlin, Shane" sort="Devlin, Shane" uniqKey="Devlin S" first="Shane" last="Devlin">Shane Devlin</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Melmed, Gil Y" sort="Melmed, Gil Y" uniqKey="Melmed G" first="Gil Y" last="Melmed">Gil Y. Melmed</name><affiliation wicri:level="2"><nlm:affiliation>Cedars-Sinai Medical Center, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Tanyingoh, Divine" sort="Tanyingoh, Divine" uniqKey="Tanyingoh D" first="Divine" last="Tanyingoh">Divine Tanyingoh</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Raffals, Laura" sort="Raffals, Laura" uniqKey="Raffals L" first="Laura" last="Raffals">Laura Raffals</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Irving, Peter" sort="Irving, Peter" uniqKey="Irving P" first="Peter" last="Irving">Peter Irving</name><affiliation wicri:level="3"><nlm:affiliation>Guy's and St Thomas' Hospitals, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy's and St Thomas' Hospitals, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kozuch, Patricia" sort="Kozuch, Patricia" uniqKey="Kozuch P" first="Patricia" last="Kozuch">Patricia Kozuch</name><affiliation wicri:level="2"><nlm:affiliation>Jefferson University, Philadelphia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Jefferson University, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Sparrow, Miles" sort="Sparrow, Miles" uniqKey="Sparrow M" first="Miles" last="Sparrow">Miles Sparrow</name><affiliation wicri:level="3"><nlm:affiliation>The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Velayos, Fernando" sort="Velayos, Fernando" uniqKey="Velayos F" first="Fernando" last="Velayos">Fernando Velayos</name><affiliation wicri:level="2"><nlm:affiliation>University of California San Francisco, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Bressler, Brian" sort="Bressler, Brian" uniqKey="Bressler B" first="Brian" last="Bressler">Brian Bressler</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Cheifetz, Adam" sort="Cheifetz, Adam" uniqKey="Cheifetz A" first="Adam" last="Cheifetz">Adam Cheifetz</name><affiliation wicri:level="2"><nlm:affiliation>Beth Israel Deaconess Medical Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Colombel, Jean Frederic" sort="Colombel, Jean Frederic" uniqKey="Colombel J" first="Jean-Frederic" last="Colombel">Jean-Frederic Colombel</name><affiliation wicri:level="2"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Siegel, Corey A" sort="Siegel, Corey A" uniqKey="Siegel C" first="Corey A" last="Siegel">Corey A. Siegel</name><affiliation wicri:level="2"><nlm:affiliation>Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. Electronic address: corey.a.siegel@hitchcock.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Hampshire</region></placeName><wicri:cityArea>Dartmouth-Hitchcock Medical Center, Lebanon</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</title><idno type="eISSN">1542-7714</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Crohn Disease (drug therapy)</term><term>Drug Therapy, Combination (adverse effects)</term><term>Drug Therapy, Combination (methods)</term><term>Drug-Related Side Effects and Adverse Reactions (epidemiology)</term><term>Drug-Related Side Effects and Adverse Reactions (pathology)</term><term>Humans</term><term>Immunologic Factors (administration & dosage)</term><term>Immunologic Factors (adverse effects)</term><term>Placebos (administration & dosage)</term><term>Randomized Controlled Trials as Topic</term><term>Treatment Outcome</term><term>Tumor Necrosis Factor-alpha (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Association de médicaments ()</term><term>Association de médicaments (effets indésirables)</term><term>Effets secondaires indésirables des médicaments (anatomopathologie)</term><term>Effets secondaires indésirables des médicaments (épidémiologie)</term><term>Essais contrôlés randomisés comme sujet</term><term>Facteur de nécrose tumorale alpha (antagonistes et inhibiteurs)</term><term>Facteurs immunologiques (administration et posologie)</term><term>Facteurs immunologiques (effets indésirables)</term><term>Humains</term><term>Maladie de Crohn (traitement médicamenteux)</term><term>Placebo (administration et posologie)</term><term>Résultat thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Immunologic Factors</term><term>Placebos</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Facteurs immunologiques</term><term>Placebo</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Drug Therapy, Combination</term><term>Immunologic Factors</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Crohn Disease</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Association de médicaments</term><term>Facteurs immunologiques</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Therapy, Combination</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladie de Crohn</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Randomized Controlled Trials as Topic</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Association de médicaments</term><term>Essais contrôlés randomisés comme sujet</term><term>Humains</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is debate over whether patients with Crohn's disease who start anti-tumor necrosis factor (TNF) therapy after failed immunomodulator therapy should continue to receive concomitant immunomodulators. We conducted a meta-analysis of subgroups from randomized controlled trials (RCTs) of anti-TNF agents to compare the efficacy and safety of concomitant immunomodulator therapy vs anti-TNF monotherapy.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Alberta</li><li>Angleterre</li><li>Californie</li><li>Grand Est</li><li>Grand Londres</li><li>Lorraine (région)</li><li>Massachusetts</li><li>Minnesota</li><li>New Hampshire</li><li>Pennsylvanie</li><li>Victoria (État)</li><li>État de New York</li></region><settlement><li>Calgary</li><li>Londres</li><li>Melbourne</li><li>Nancy</li></settlement><orgName><li>Université de Calgary</li><li>Université de Lorraine</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Jones, Jennifer L" sort="Jones, Jennifer L" uniqKey="Jones J" first="Jennifer L" last="Jones">Jennifer L. Jones</name></noRegion><name sortKey="Bressler, Brian" sort="Bressler, Brian" uniqKey="Bressler B" first="Brian" last="Bressler">Brian Bressler</name><name sortKey="Devlin, Shane" sort="Devlin, Shane" uniqKey="Devlin S" first="Shane" last="Devlin">Shane Devlin</name><name sortKey="Kaplan, Gilaad G" sort="Kaplan, Gilaad G" uniqKey="Kaplan G" first="Gilaad G" last="Kaplan">Gilaad G. Kaplan</name><name sortKey="Tanyingoh, Divine" sort="Tanyingoh, Divine" uniqKey="Tanyingoh D" first="Divine" last="Tanyingoh">Divine Tanyingoh</name></country><country name="France"><region name="Grand Est"><name sortKey="Peyrin Biroulet, Laurent" sort="Peyrin Biroulet, Laurent" uniqKey="Peyrin Biroulet L" first="Laurent" last="Peyrin-Biroulet">Laurent Peyrin-Biroulet</name></region></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Baidoo, Leonard" sort="Baidoo, Leonard" uniqKey="Baidoo L" first="Leonard" last="Baidoo">Leonard Baidoo</name></region><name sortKey="Cheifetz, Adam" sort="Cheifetz, Adam" uniqKey="Cheifetz A" first="Adam" last="Cheifetz">Adam Cheifetz</name><name sortKey="Colombel, Jean Frederic" sort="Colombel, Jean Frederic" uniqKey="Colombel J" first="Jean-Frederic" last="Colombel">Jean-Frederic Colombel</name><name sortKey="Kozuch, Patricia" sort="Kozuch, Patricia" uniqKey="Kozuch P" first="Patricia" last="Kozuch">Patricia Kozuch</name><name sortKey="Melmed, Gil Y" sort="Melmed, Gil Y" uniqKey="Melmed G" first="Gil Y" last="Melmed">Gil Y. Melmed</name><name sortKey="Raffals, Laura" sort="Raffals, Laura" uniqKey="Raffals L" first="Laura" last="Raffals">Laura Raffals</name><name sortKey="Siegel, Corey A" sort="Siegel, Corey A" uniqKey="Siegel C" first="Corey A" last="Siegel">Corey A. Siegel</name><name sortKey="Velayos, Fernando" sort="Velayos, Fernando" uniqKey="Velayos F" first="Fernando" last="Velayos">Fernando Velayos</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Irving, Peter" sort="Irving, Peter" uniqKey="Irving P" first="Peter" last="Irving">Peter Irving</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Sparrow, Miles" sort="Sparrow, Miles" uniqKey="Sparrow M" first="Miles" last="Sparrow">Miles Sparrow</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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